In search of a combined brucellosis and tuberculosis vaccine for cattle

نویسندگان

چکیده

Bovine brucellosis is caused by Brucella abortus. The bacterial pathogen causes economic losses because it induces abortion in cattle. Vaccination of calves with live B. abortus strain 19 a certain level protection but persistent antibodies against cell envelope lipopolysaccharide that make difficult to Distinguish Infected from Vaccinated Animals (DIVA). Live vaccine RB51 was developed eliminate such interfering and therefore, facilitate the differentiation infected vaccinated animals help eradication disease. levels similar neither two vaccines give complete protection. We have been working enhance induced vaccine. Protective antigens can be over-expressed introducing plasmid containing leuB gene genes encoding antigens. To avoid expression antibiotic resistance genes, we produced deficient introduced over-expressed. This new maintains has significantly high mice. In addition, allowed construction an able express Mycobacterium bovis protective so could protect tuberculosis simultaneously.

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ژورنال

عنوان ژورنال: Austral journal of veterinary sciences

سال: 2021

ISSN: ['0719-8000', '0719-8132']

DOI: https://doi.org/10.4067/s0719-81322021000100001